kuongororwa kwekliniki yemigumisiro ye-anti-allergic mattress inovhara kune varwere vane mwero kusvika kune yakanyanya asthma uye imba yeguruva mite allergy: randomized double blind placebo controlled study.

Background: Kushandisa
Allergic mattress inovhara muvarwere veasthma inogona kutungamira mukudzikiswa kwakakosha kwehuwandu hwehupfu hwemba muhupfu samples.
Pamusoro pematishu amine-induced yakaderera airway hyperresponsiveness, pane zvishoma data kuratidza kukanganisa kwematiresi inovhara pahutano hwekiriniki uye hupenyu hwehupenyu kune varwere vane pakati kusvika kune yakanyanya asima.
Nzira: Varwere makumi matatu vane asthma uye imba guruva mites allergy vakadzidzwa mune randomized, double-blind, placebo-controlled controlled study.
Pamberi uye mushure mekushandisa
Allergy chivharo kwegore 1 unganidza huruva kubva pamatiresi kuti uone kuzara kwedermat muImba (Der p 1)
Iyo airway hyperreactivity uye hupenyu hwehupenyu hwakayerwa.
Murwere akawana zviratidzo (mapapu nemhino)
, Mangwanani uye manheru peak kuyerera kukosha, kununura mishonga 14 mazuva asati uye mushure mekupindira.
Migumisiro: kana ichienzaniswa nekutanga kurapwa, kusanganiswa kweDer p1 muguruva rakaunganidzwa nemattress muboka rinoshanda rekurapa rakaderera zvikuru mushure megore re1;
Hapana shanduko yawanikwa muboka re placebo.
Mukurapa kunoshanda uye mapoka e placebo, pakanga pasina kuvandudzwa kwakakosha muPC20 tishu amine.
Unhu hwehupenyu mumapoka ose ari maviri hwakavandudzika zvakafanana.
Mumapoka ose ari maviri, pakanga pasina kuchinja kukuru muchiratidzo chechiratidzo chezasi chemhepo.
Kuenzaniswa nekutanga kurapwa, chiratidzo chemhino cheboka rinoshanda rekurapa chakaderera zvakanyanya, asi pakanga pasina kusiyana kukuru pakati pemapoka maviri.
Hapana boka rakawana shanduko mangwanani nemanheru peak kuyerera kukosha, peak flow variability, uye kununura kushandiswa kwezvinodhaka.
Mhedziso: Shandisa kuramba
Allergic mattress coverage inotungamira kudzikira kwakanyanya muDer p1 concentration mumakamuri ekurara asina kapeti.
Nekudaro, muvarwere vane mwero kusvika kune yakanyanya asima, iyi inoshanda allergen kudzivirira haikanganisi airway hyperresponsiveness uye kiriniki paramita.
Nzira kubva muna Ndira 1996 kusvika Zvita 1998, varwere makumi matatu nemasere vane makore 11-44 vane nhoroondo yeasthma uye guruva remumba vakatorwa kubva kukiriniki yeasthma muHilverum, Netherlands.
Mvumo ine ruzivo yakawanikwa kubva kumurwere kana kubva kuvabereki vake.
Varwere ava vakasarudzwa zvichienderana nekuwedzera kwekupindura kwemhepo kune inhalation ye tissue amine (
PC20 1 μ g Der p 1/g guruva).
Kupfuura 60% yevarwere vese (Forecast value).
Varwere vakanga vasina nhoroondo yezvirwere zvekufema mumavhiki ekupedzisira e6 uye vakanga vasina kurwisa kwakanyanya kweasthma mumwedzi mitanhatu yapfuura.
Mumwedzi mitanhatu yapfuura, hapana akagamuchira oral steroids.
Varwere vese vaive vazivisa mvumo.
Komiti yezvekurapa yeAsthmacenter heuvel yakatendera chidzidzo ichi.
Chidzidzo magadzirirwo chidzidzo ichi chaive chakasarudzika, placebo-inodzorwa, kaviri-mapofu, parallel-boka dhizaini iyo yakaenzanisa mhedzisiro yealeji isiri-yekupinza packaging pamamatiresi, mapillow, uye anovhara mibhedha mukati megore 1 uye inofananidzwa neplacebo kurongedza.
Pakutanga kwechidzidzo, mukoti akadzidzira kufema akashanyira murwere, akaunganidza masampula eguruva kubva pametiresi yemurwere yeDer p1 zviyero, uye akarekodha nhanho dzekudzivirira allergen dzaive dzatovapo kumba.
Varwere vese vaisanganisirwa muchidzidzo vaive nedzimba dzekurara dzakatsetseka.
Murwere akarairwa kuchenesa mapepa pa60 °c pasvondo
Pamusoro pekurongedza metiresi, hapana mamwe matanho akatorwa kudzivirira allergens.
Pakapera chidzidzo chacho, mukoti mumwe chete iyeye akashanyira dzimba dzacho zvakare kuti atore huruva kubva pamapedhi emubhedha.
Murwere akabatanidzwa gore rose;
Nguva yekubatanidzwa ndeye 2 makore.
Varwere vane pollen allergies vakaongororwa kunze kwemwaka wekume.
Pakushanya kwekutanga, murwere akaongororwa kliniki.
Hupenyu kugona (VC)
Mitemo yakayerwa, kuongororwa kweganda kwakaitwa, uye PC20 tishu Amine yakaongororwa.
Rega kutora zvinodhaka nguva isati yasvika: Inhaled steroids uye sodium acetate kwevhiki 1 isati yasvika trachea tissue amine stimulation test;
Kuongororwa kusati kwaitwa, theophylline, oral beta 2 adrenaline zvinodhaka, kwenguva refu-yakafema beta 2 adrenaline zvinodhaka, uye antihistine yakagara kwemaawa makumi mana nemasere, uye kufema kweiyo pfupi-acting beta 2 adrenaline zvinodhaka kwakatora maawa matanhatu.
Kuunganidzwa uye kubviswa kweguruva reimba pamberi, 4 uye 8 mwedzi yekupindira uye pakupera kwekupindira inounganidzwa neiyo imwechete vacuum cleaner (
Philips Vitall 377,1300 Watt, Philips, Eindhoven, Netherlands)
Shandisa yakakosha kusefa mudziyo kubva kune yese metiresi mumaminetsi maviri (
ALK muholsham, Denmark).
Pakutanga kwekudzidza, unganidza guruva zvakananga kubva pamatiresi;
Pakupera kwechidzidzo, huruva yakaunganidzwa pamusoro pemusasa.
Iyo sefa inochengetwa mufiriji pa-20 °c kusvikira ongororo yaitwa pakupera kwechidzidzo.
Kutsunga kweDer P1 antigen na elisa (ELISA).
Monoclonal antibody inopesana neDer p1 yakagadziriswa pa96-tsime ndiro.
Mushure mekunyudzwa neguruva rinobviswa, danho rechipiri rakaiswa neakawanda-valent antibody (
Sunflower over-enzyme.
Mushure mekuwedzera 1, 2-
Nezve diamine HCl (OPD)
Se substrate, kunyura pa490 nm kwakayerwa uchishandisa ELISA muverengi.
Tissue amine phosphate solution (
Kaviri concentration kubva ku0. 25 kusvika 32 mg / ml)
Inotungamirirwa kuburikidza neDe Vilbiss 646 nebulizer ine kubuda kwe0. 13 mg/ml.
Iyo nebulizer yakaiswa pabhokisi revharuvhu rine aerosol sefa.
Nguva yeatomization yaive masekondi makumi matatu panguva iyo murwere akarairwa kufema chinyararire.
Chiyedzo ichi chakatanga nekufemerwa kwephosphate buffer aerosol.
Zviyero zvitatu zveVC uye fev pamberi pekufema (
Masterscreen).
V1 yakayerwa mushure mekugadzirisa kwega kwega.
PC20 tishu amine inotorwa nemutsara kududzira.
Mattresses, mapillow nemabed eboka rekupindira zvakaputirwa muLID yakapihwa naCarla c\'air (
Allergy Control AC btm Velserbroek, Netherlands).
Chivharo cheplacebo chinoenderana chakagadzirwa nekambani imwechete.
Musasa wacho, wakarongwa nemukoti wekutsvakurudza, wakagara panzvimbo ye1 gore.
Hunhu hwehupenyu kuburikidza nemhando yehupenyu mibvunzo yezvirwere zvekufema (QoL-RIQ). 17
RIQ imhando yehutano hwehupenyu hwemibvunzo yevarwere vane asima uye isingaperi asthma, inosanganisira zvinhu makumi mashanu neshanu, zvakakamurwa kuita nzvimbo nomwe: matambudziko ekufema (9 zvinhu)
Matambudziko emuviri (9 zvinhu), manzwiro (9 zvinhu)
, Tangisa / wedzera mamiriro ekufema matambudziko (7 zvinhu)
Zviitwa zvakajairika (4 zvinhu)
Mabasa ezuva nezuva uye epamba (10 zvinhu)
Zviitiko zvemagariro, hukama hwevanhu uye zvepabonde (7 zvinhu).
Kuti titarise dambudziko pane zvakaitika kumurwere, chirongwa chinobva pa "dambudziko rakadii" ravanosangana naro kubva muzviratidzo kana manzwiro ari pamusoro.
Panyaya yemapurojekiti ane chekuita nemabasa, mubvunzo ndewekuti \"zvakatadziswa zvakadii mukuita chiitiko ichi".
Varwere vakakumbirwa kuti vape mhinduro dzavo pachikero che70-point Likert, kubva \"kwete zvachose" kusvika \"kunyanya" kushushikana kana kuvhiringidza. Kuvimbika (test-
Kuongororazve, kuenderana kwemukati)
Uye yakaratidza kushanda kwayo.
17 kliniki parameters panguva ye14-zuva risati rapindira uye pakupera kwemwedzi we12 wakaoma kutarisira kunoda kuti varwere vanyore diary makadhi easthma uye zviratidzo zvemhino, peak flow values, uye kunyora mishonga kaviri pazuva.
Zviratidzo zveasthma zvinosanganisira kutadza kufema, kukosora, kukosora nekufema.
Zviratidzo zvemhino zvinosanganisira kusangana kwemhino, kuhotsira nekukwenya.
Chinhu chega chega chakakamurwa kubva ku0 mapoinzi (hapana zviratidzo) kuenda ku4 (Yakanyanya zviratidzo).
Varwere vakadzidziswa kuita peak flow drills vachishandisa micro-equipmentWright mita.
Vakarayirwa kuti vaite kuverenga katatu uye kunyora zvakakosha zvikuru pavakamuka mangwanani uye vasati vaenda kunorara usiku.
Varwere vakakumbirwa kuti vaenderere mberi nemishonga yakajairika yekufema uye kunyora imwe salvage mishonga kana vachizoida.
Kuongororwa kwedata uye kuongororwa kwenhamba kwakaitwa neSPSS.
Kuenzanisa kweboka (
Pamberi uye mushure mekupindira)
Yakaitwa neWilcoxon siginecha ongororo.
Ongorora data regi uchishandisa bvunzo dzezviratidzo. The Mann-
Muedzo weWhitney U wakashandiswa kuenzanisa pakati peboka. p kukosha kwe0. 5)
Muboka rekurapa uye boka re placebo, pakanga paine 18 mapoinzi ematambudziko ekufema, matambudziko emuviri ane chekuita nedambudziko rechipfuva, trigger / enhancement, uye yakazara mamaki.
Kunyange zvazvo pakanga pasina misiyano yakakura mumuganhu wekuvandudza pakati pemapoka maviri, kuvandudzwa mukati meboka rekurapa kwakakosha.
Ikoko kwakanga kusina mutsauko wakakosha muhutano hwekutanga hwemakiriniki emagetsi ezviratidzo zvechirwere cheasthma pakati pemapoka (tafura 2).
Chiratidzo chechiratidzo chepakati chepakati chemapoka maviri haana kuchinja zvakanyanya mukati megore re1.
Chiratidzo chemhino cheboka rekurapa chakadzikira zvakanyanya (p=0. 04)
Asi kwete muboka re placebo.
Musiyano wemapoka maviri aya wakanga usina kukosha.
Baseline ef value (
Mangwanani nemanheru)
Mapoka maviri aya anofananidzwa (tafura 3).
Mushure megore re1 rekupindira, pakanga pasina kuchinja kukuru mangwanani uye manheru ef, peak flow variability kana kushandiswa kwemishonga yekununura mumapoka maviri evarwere.
Tarisa tafura iyi: Wona iyo inline Tarisa pop-up tafura 2 chiratidzo chechiratidzo pamberi uye mushure mekupindira (
Kunyoreswa kweMedhiya mumazuva gumi nemana)
Tarisa tafura iyi: Wona iyo inline Tarisa pop-up tafura 3 peak traffic kukosha pamberi uye mushure mekupindira (
Kunyoreswa kweMedhiya mumazuva gumi nemana)
Chinangwa chechidzidzo ichi ndechekudzidza
Mune allergic metiresi pasuru mukamuri yekurara isina kapeti, yakavhenekerwa neDer p1 pamubhedha, allergic kune guruva remba muvarwere vane pakati kusvika kune yakanyanya asima.
Takawana kuderera kukuru muhuwandu hweDer p1 muguruva rakaunganidzwa nemateti muboka rinoshanda rekurapa rinoenzaniswa neboka re placebo.
PC20 tishu Amine haina kuvandudza panguva yekupindira kwe1-gore.
Kunyange zvazvo kuvandudzwa kwakakosha kwezviratidzo zvemhino uye mararamiro ehupenyu zvakaonekwa chete muboka rinoshanda rekurapa, hatina kuwana misiyano yakakura pakati peboka re placebo neboka rinoshanda rekurapa mukuchinja kwemapapu uye zviratidzo zvemhino, hupenyu hwehupenyu, huwandu hwepamusoro hwekuyerera, uye kushandiswa kwemishonga yekununura.
Zvidzidzo zvepakutanga zvichishandisa akati wandei akasiyana mattress ekurongedza zvakaratidzawo kudzikira kweDer p1 kuratidzwa pamusoro pemetiresi (tafura 4).
Zvisinei, zvimwe zvidzidzo hazvina kuratidza kuderera kwehuwandu hweDer p1, uye mune zvidzidzo izvi kapeti muimba yekurara haina kubviswa.
21,22 isu tinobvisa iyo Der p1 kusvibiswa nyaya kubva pasi 13 nekubatanidza varwere chete vasina kapeti mukamuri yekurara.
Izvi zvinogona kutungamira kune chokwadi chekuti, kunyangwe yedu yekutanga Der p1 yekumisikidza yakakwira kupfuura zvimwe zvidzidzo, tinogona kuderera zvakanyanya muboka rinorapwa.
22, 23 kudzikira kwekusagadzikana kweallegen kwakasvika mushure memwedzi mina uye yakaramba isina kuchinjika mukati menguva yese yekudzidza.
Ona tafura iyi: Ona inline View pop-up table 4 Pfupiso yemigumisiro uye zvigadziro zvekudzivirira mattress kuvhara chidzidzo kunyange zvazvo kukanganiswa kweDer p1 muboka rinoshanda rekurapa kwakaderedzwa zvakanyanya kana ichienzaniswa neboka re placebo, hatina kuwana kuderera kukuru mumhepo ye hyperresponsiveness.
Zvimwe zvidzidzo zvakakundikanawo kuratidza kuvandudzwa kwemhepo ye hyperresponsiveness.
Zvidzidzo zviviri 22, 23, 10, 11, 22 hazvina kuwana kuderera kukuru kweallegen concentration muguruva, iyo yakatsanangura kushayikwa kwekuvandudzwa kwemhepo hyperreactivity.
Frederick et al akataura kuti varwere vese vaidzorwa zvine musoro mukurapa kwekudzivirira, saka pakanga paine shanduko shoma kana kusavepo mumakiriniki paramita.
Kunyange Cloosterman nevamwe vaaishanda navo, 11 vanhu vakaedza kudzivisa chiitiko ichi chekurapa nekubatanidza chete varwere vasina kushandisa inhaled steroids kana kuti vakakwanisa kuvamisa, havana kuwana kuvandudzwa kwakakosha mumhepo hyperresponsiveness, hapana kuvandudzwa kunokosha mune chero ipi zvayo yemakiriniki emakiriniki anoshandiswa, zvakadai sezviratidzo zvechiratidzo, ef variability, uye reversible yeF1.
Tingabatanidza sei maonero aya?
Pasinei nehuwandu hwepamusoro hwe cortisol yakafemerwa, varwere vanobatanidzwa muchidzidzo chedu vaive nehutsinye hwakanyanya (> 800 μg)
Mukusiyana, iyo PC20